https://ogma.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:46793 Wed 30 Nov 2022 14:10:23 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:12681 Wed 28 Oct 2020 09:39:58 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:51174  95th percentile for age < 18 years, and systolic BP > 130 and/or diastolic BP > 80 mmHg for age ≥ 18 years. Multivariable Generalised Estimating Equations were used to examine demographic and clinical factors associated with BP in the hypertensive range across all visits. Results: Data from 6338 young people (male 52.6%) attending 24 participating centres across 36,655 T1D healthcare visits were included; 2812 (44.4%) had BP recorded at last visit. Across all visits, 19.4% of youth aged < 18 years and 21.7% of those aged ≥ 18 years met criteria for hypertension. In both age groups, BP in the hypertensive range was associated with male sex, injection (vs. pump) therapy, higher HbA1c, and higher body mass index. Conclusions: There is a high proportion of adolescents and young adults reported with BP persistently in hypertensive ranges. Findings flag the additive contribution of hypertension to the well-established body of evidence indicating a need to review healthcare models for adolescents and young adults with T1D.]]> Wed 28 Feb 2024 15:58:15 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:52384 Wed 28 Feb 2024 15:35:45 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:44991 Wed 26 Oct 2022 09:28:24 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:12716 Wed 24 Jul 2013 22:25:37 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:44073 Wed 22 Mar 2023 15:46:47 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:48511 n = 321,223) and offspring birth weight (n = 230,069 mothers), we identified 190 independent association signals (129 of which are novel). We used structural equation modeling to decompose the contributions of direct fetal and indirect maternal genetic effects, then applied Mendelian randomization to illuminate causal pathways. For example, both indirect maternal and direct fetal genetic effects drive the observational relationship between lower birth weight and higher later blood pressure: maternal blood pressure-raising alleles reduce offspring birth weight, but only direct fetal effects of these alleles, once inherited, increase later offspring blood pressure. Using maternal birth weight-lowering genotypes to proxy for an adverse intrauterine environment provided no evidence that it causally raises offspring blood pressure, indicating that the inverse birth weight-blood pressure association is attributable to genetic effects, and not to intrauterine programming.]]> Wed 22 Mar 2023 15:25:15 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:41782  0.05). Our findings suggest that the inverse association of birthweight with hypertension risk from observational studies was not supported by large Mendelian randomization analyses.]]> Wed 22 Mar 2023 14:30:25 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:42269 Wed 20 Sep 2023 12:13:03 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:33058 Wed 15 Dec 2021 16:09:20 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:19636 Wed 11 Apr 2018 14:36:07 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:20481 Wed 11 Apr 2018 14:29:37 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:16581 Wed 11 Apr 2018 14:11:56 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:22232 Wed 11 Apr 2018 13:37:53 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:25219 Wed 11 Apr 2018 13:26:52 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:30728 n = 6746; mean age 58 years old; SD 17; 41% men; 31% hypertensive) and South Africa (n = 3776, mean age 54 years old; SD 17; 32% men; 45% hypertensive). South Africans were more likely than Ghanaians to add salt to food at the table (OR 4.80, CI 4.071–5.611, p < 0.001) but less likely to add salt to food during cooking (OR 0.16, CI 0.130–0.197, p < 0.001). South Africans were also less likely to take action to control their salt intake (OR 0.436, CI 0.379–0.488, p < 0.001). Considering the various salt reduction initiatives of South Africa that have been largely absent in Ghana, this study supports additional efforts to raise consumer awareness on discretionary salt use and behaviour change in both countries]]> Wed 11 Apr 2018 11:24:40 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:14864 Wed 11 Apr 2018 10:29:15 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:24519 Wed 09 Mar 2022 16:03:44 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:34209 Wed 09 Feb 2022 15:53:11 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:29040 Wed 07 Jul 2021 12:14:25 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:37187 2), middle-aged (35-65 years old) men. Participants were recruited in May 2018, and the intervention took place between June and December 2018. The intervention involved 12 weekly 90-min face-to-face sessions, incorporating physical activity, nutrition, and behaviour change information and practical activities delivered by coaches at 2 clubs. Data were collected at baseline and immediately postintervention. For trial feasibility purposes, 6-month follow-ups were completed. Outcomes were differences in weight loss (primary outcome) and recruitment and retention rates, self-reported measures (for example, psychological well-being), device-measured physical activity, waist size, and blood pressure at 3 months. Within 3 days of advertising at each club, 426 men registered interest; 306 (72%) were eligible. Men were selected on a first-come first-served basis (n = 130; M age = 45.8, SD = 8; M BMI = 34.48 kg/m² SD = 4.87) and randomised by a blinded researcher. Trial retention was 86% and 63% at 3- and 6-month follow-ups (respectively). No adverse events were reported. At 3 months, mean difference in weight between groups, adjusted for baseline weight and group, was 3.3 kg (95% CI 1.9, 4.8) in favour of the intervention group (p < 0.001). The intervention group's moderate-to-vigorous physical activity (MVPA) was higher than the control group by 8.54 min/day (95% CI 1.37, 15.71, p = 0.02). MVPA among men attracted to Aussie-FIT was high at baseline (intervention arm 35.61 min/day, control arm 38.38 min/day), which may have limited the scope for improvement. Conclusion: Aussie-FIT was feasible to deliver; participants increased physical activity, decreased weight, and reported improvements in other outcomes. Issues with retention were a limitation of this trial. In a future, fully powered randomised controlled trial (RCT), retention could be improved by conducting assessments outside of holiday seasons.]]> Wed 07 Apr 2021 20:21:06 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:16811 Tue 31 Jul 2018 13:38:25 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:43670 refl), and the augmentation index (AI), assuming a general extended model of the arterial system. Then, we test the proposed model against values reported in the literature. Finally, we discuss insights from the model to common observations in the literature such as age-related “shift” in the reflection site, the variation of AI with heart rate, and the flattening of T_refl in older participants.]]> Tue 27 Sep 2022 15:14:55 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:22165 40% of energy) intakes. There may be an ideal maternal macronutrient ratio associated with optimal infant BP. Maternal diet, which is potentially modifiable, may play an important role in influencing offspring risk of future hypertension.]]> Tue 24 Apr 2018 11:39:46 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:41918 Tue 16 Aug 2022 14:24:31 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:36119 Tue 11 Feb 2020 11:47:06 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:51430 Tue 05 Sep 2023 17:47:25 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:36190 measured during nighttime ambulatory BP monitoring (ABPM) and basal MAP estimated using a standardized protocol. Materials and methods: For a cohort of 137 consecutive patients, aged ≥40 years, who recently underwent ABPM, a blinded investigator estimated basal MAP from up to five most recent clinic BP measurements. Both basal MAP values, measured and estimated, were compared pairwise for each participant. Results: We traced a median of 4 [interquartile range 3-5] previous BP measurements per patient over a median period of 132 [interquartile range 55-277] days up until the ABPM test. The estimated basal MAP (mean 88 ± 8 mmHg) was linearly related (Pearson's r = 0.41, p = 0.0001) to the measured basal MAP (mean 88 ± 12 mmHg). Bland-Altman plot revealed a mean bias of 0.3 mmHg with agreement limits of ±22 mmHg. Conclusions: The mean bias between estimated and measured values for basal MAP was insignificant and modest. When a recent nighttime ABPM is unavailable, a protocol based on recent clinic BP readings can be used to estimate patient's basal MAP. Study registration: Australian New Zealand Clinical Trials Registry ACTRN12613001382763.]]> Thu 27 Feb 2020 09:35:33 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:656 Thu 25 Jul 2013 09:10:28 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:496 Thu 25 Jul 2013 09:09:56 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:179 Thu 25 Jul 2013 09:09:31 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:51192 150 mm Hg) after thrombolysis treatment for acute ischaemic stroke between March 3, 2012 and April 30, 2018. Methods: All available brain imaging were analysed centrally by expert readers. Log-linear regression was used to determine the effects of intensive blood pressure lowering on the size of cerebral infarction, with adjustment for potential confounders. The primary analysis pertained to follow-up computerised tomography (CT) scans done between 24 and 36 h. Sensitivity analysis were undertaken in patients with only a follow-up magnetic resonance imaging (MRI) and either MRI or CT at 24–36 h, and in patients with any brain imaging done at any time during follow-up. This trial is registered with ClinicalTrials.gov, number NCT01422616. Findings: There were 1477 (67.3%) patients (mean age 67.7 [12.1] y; male 60%, Asian 65%) with available follow-up brain imaging for analysis, including 635 patients with a CT done at 24–36 h. Mean achieved systolic blood pressures over 1–24 h were 141 mm Hg and 149 mm Hg in the intensive group and guideline group, respectively. There was no effect of intensive blood pressure lowering on the median size (ml) of cerebral infarction on follow-up CT at 24–36 h (0.3 [IQR 0.0–16.6] in the intensive group and 0.9 [0.0–12.5] in the guideline group; log Δmean −0.17, 95% CI −0.78 to 0.43). The results were consistent in sensitivity and subgroup analyses. Interpretation: Intensive blood pressure lowering treatment to a systolic target <140 mm Hg within several hours after the onset of symptoms may not increase the size of cerebral infarction in patients who receive thrombolysis treatment for acute ischaemic stroke of mild to moderate neurological severity. Funding: National Health and Medical Research Council of Australia; UK Stroke Association; UK Dementia Research Institute; Ministry of Health and the National Council for Scientific and Technological Development of Brazil; Ministry for Health, Welfare, and Family Affairs of South Korea; Takeda.]]> Thu 24 Aug 2023 14:38:31 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:54919 Thu 21 Mar 2024 13:13:19 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:43237 Thu 15 Sep 2022 11:13:29 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:32882 0.05) after adjustment for pretreatment values, treatment period, and treatment order. Similarly, no differences were observed between treatments for arterial stiffness measures (P > 0.05). Conclusion: Increased intake of nitrate-rich vegetables did not lower blood pressure in prehypertensive or untreated grade 1 hypertensive individuals when compared with increased intake of nitrate-poor vegetables and no increase in vegetables.]]> Thu 13 Oct 2022 17:10:46 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:44094 3 seconds perfusion lesion with severely delayed contrast transit (delay time >3 seconds/delay time >6 seconds). Results: There were 306 patients included in this study. With every increase of 10 mmHg in baseline systolic blood pressure, the odds of achieving an excellent functional outcome decreased by 12% in multivariate analysis (odds ratio = 0.88, p = 0.048). Conversely, increased baseline blood pressure was associated with better collateral flow. In subgroup analysis of patients with major reperfusion, higher blood pressure was associated with decreased infarct growth and a better clinical outcome, and vice versa in patients without reperfusion. Interpretation: Higher baseline blood pressure in acute ischemic stroke patients with large vessel occlusion/stenosis was associated with better collateral flow. However, for patients without reperfusion, higher baseline blood pressure was associated with increased infarct growth, leading to an unfavorable clinical outcome. The relationship between blood pressure and outcomes is highly dependent on reperfusion, and active blood pressure–lowering treatment may be inappropriate in acute ischemic stroke patients prior to reperfusion treatment.]]> Thu 06 Oct 2022 16:16:26 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:8125 Sat 24 Mar 2018 08:40:02 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:8359 Sat 24 Mar 2018 08:39:50 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:7056 Sat 24 Mar 2018 08:37:56 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:6990 0.08). In the secondary analyses, weighting each of the data points according to the lengths of the respective follow-up intervals, the flavour of both home-cooked foods (mean difference = -1.8 mm, P=0.045) and a standard salty soup (mean difference = -1.9mm, P=0.03) was slightly weaker in the salt substitute group. We conclude that salt substitution is both an effective and an acceptable means of blood pressure control. Possible small differences in flavour did not importantly deter the use of the salt substitute in this study group, although the acceptability of the salt substitute by a more general population group would need to be confirmed.]]> Sat 24 Mar 2018 08:37:48 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:9366 Sat 24 Mar 2018 08:36:32 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:1947 Sat 24 Mar 2018 08:33:19 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:2925 Sat 24 Mar 2018 08:32:18 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:1886 Sat 24 Mar 2018 08:31:18 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:1162 Sat 24 Mar 2018 08:28:43 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:1436 Sat 24 Mar 2018 08:28:03 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:14331 2. The median time from first to last radiofrequency energy ablation was 38 minutes. The procedure was without complication in 97% of patients (149 of 153). The 4 acute procedural complications included 3 groin pseudoaneurysms and 1 renal artery dissection, all managed without further sequelae. Postprocedure office BPs were reduced by 20/10, 24/11, 25/11, 23/11, 26/14, and 32/14 mm Hg at 1, 3, 6, 12, 18, and 24 months, respectively. In conclusion, in patients with resistant hypertension, catheter-based renal sympathetic denervation results in a substantial reduction in BP sustained out to ≥2 years of follow-up, without significant adverse events.]]> Sat 24 Mar 2018 08:26:21 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:12722 Sat 24 Mar 2018 08:18:25 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:12700 Sat 24 Mar 2018 08:18:24 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:12687 Sat 24 Mar 2018 08:16:55 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:12662 35 mm Hg) in the rabbit, muscle blood flow did not change, although cardiac output increased. During moderate hypoxia (Po₂ 30 - 35 mm Hg) there was initial vasoconstriction in muscle, followed by a return to control values paralleling the changes in cardiac output. In severe arterial hypoxia (Po₂ < 30 mm Hg) the initial vasoconstriction was less marked, and during the 'steady state' there was a large vasodilatation and increase in muscle blood flow, at a time when the cardiac output was not elevated. 3. The early vasoconstriction in arterial hypoxia is mediated mainly through sympathetic vasoconstrictor nerves as a result of strong arterial chemoreceptor stimulation. 4. Increased secretion of adrenaline is an important factor in restoring muscle blood flow to control values during moderate arterial hypoxia, and in elevating the muscle blood flow above these values in severe hypoxia. The peripheral dilator (β-)effects of adrenaline oppose the peripheral constrictor (α-) effects resulting from increased activation of sympathetic constrictor nerves during arterial hypoxia.]]> Sat 24 Mar 2018 08:15:49 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:11295 0.1). Approximately 71% of SBP readings with the DESK position were within ±10 mmHg, whereas it was 62.5% and 34% for HORIZONTAL and SHOULDER positions, respectively. Wrist DBP attained category D with BHS criteria with all three arm positions. Bland–Altman plots illustrated that the wrist monitor systematically underestimated SBP and DBP values. However a reading adjustment of 5 and 10 mmHg for SBP and DBP (DESK position) resulted in improvement with 75% and 77% of the readings being within 10 mmHg (grade B), respectively. AAMI criteria were not fulfilled due to heterogeneity. The findings also showed that the mismatch between the mercury and wrist-cuff systolic BP readings was directly associated with pulse pressure. In conclusion the DESK position produces the most accurate readings when compared to the mercury device. Although wrist BP measurement may underestimate BP measured compared to a mercury device, an adjustment by 5 and 10 mmHg for SBP and DBP, respectively, creates a valid result with the DESK position. Nevertheless, considering the observed variations and the possible impact of arterial stiffness, individual clinical validation is recommended.]]> Sat 24 Mar 2018 08:11:59 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:10798 Sat 24 Mar 2018 08:10:05 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:10744 Sat 24 Mar 2018 08:08:21 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:10746 Sat 24 Mar 2018 08:08:20 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:21419 P=0.02), diastolic (P=0.01), and arterial blood pressures (P=0.002), respectively, 5 years later. In girls, each 1-SD increase in dietary glycemic index, glycemic load, carbohydrate, and fructose was concurrently related to increases of 1.81 (P=0.001), 4.02 (P=0.01), 4.74 (P=0.01), and 1.80 mm Hg (P=0.03) in systolic blood pressure, respectively, >5 years. Significant associations between carbohydrate nutrition variables and blood pressure were not observed among boys. Excessive dietary intake of carbohydrates, specifically from high glycemic index/glycemic load foods, could adversely influence blood pressure, particularly in girls, whereas fiber-rich diets may be protective against elevated blood pressure during adolescence.]]> Sat 24 Mar 2018 08:05:02 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:21149 Sat 24 Mar 2018 08:00:16 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:18932 Sat 24 Mar 2018 07:58:58 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:5617 Sat 24 Mar 2018 07:49:23 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:5186 Sat 24 Mar 2018 07:47:48 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:4972 Sat 24 Mar 2018 07:46:54 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:27845 Sat 24 Mar 2018 07:41:17 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:27092 Sat 24 Mar 2018 07:40:35 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:26366 Sat 24 Mar 2018 07:33:07 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:27521 Sat 24 Mar 2018 07:28:55 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:25141 Sat 24 Mar 2018 07:17:11 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:46667 International Statistical Classification of Diseases and Related Health Problems (Tenth Edition, Australian Modification) codes from the hospital admissions and emergency presentation data. The outcome variable and other system factors were derived from the Australian Stroke Clinical Registry dataset. Multivariable, multilevel logistic regression was used to examine factors associated with the prescription of antihypertensive medications at hospital discharge. Results: Of the 10 315 patients included, 79.0% (intracerebral hemorrhage, 74.1%; acute ischemic stroke, 79.8%) were prescribed antihypertensive medications at discharge. Prescription varied between hospital sites, with 6 sites >2 SDs below the national average for provision of antihypertensives at discharge. Prescription was also independently associated with patient and clinical factors including history of hypertension, diabetes mellitus, management in an acute stroke unit, and discharge to rehabilitation. In patients with acute ischemic stroke, females (odds ratio, 0.85; 95% CI, 0.76-0.94), those who had greater stroke severity (odds ratio, 0.81; 95% CI 0.72-0.92), or dementia (odds ratio, 0.65; 95% CI, 0.52-0.81) were less likely to be prescribed. Conclusions: Prescription of antihypertensive medications poststroke varies between hospitals and according to patient factors including age, sex, stroke severity, and comorbidity profile. Implementation of targeted quality improvement initiatives at local hospitals may help to reduce the variation in prescription observed.]]> Mon 28 Nov 2022 18:46:24 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:18939 Mon 27 Jul 2015 11:51:12 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:46976 Mon 12 Dec 2022 16:54:26 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:4348 Mon 08 Apr 2019 09:49:35 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:37624 Mon 01 Mar 2021 15:54:04 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:12670 Fri 27 Sep 2019 16:03:24 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:12671 Fri 27 Sep 2019 15:57:40 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:40030 Fri 22 Jul 2022 13:07:48 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:42280 Fri 19 Aug 2022 14:51:53 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:54824 Fri 15 Mar 2024 09:11:39 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:41815 Fri 12 Aug 2022 12:45:25 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:46103 185/105 mmHg) during the first 24 h following tPA-bolus. The majority of BP excursions (46%) occurred within the first 75 min from tPA-bolus. Patients with at least one BP excursion in the first 24 h following tPA bolus had significantly lower rates of independent functional outcome at 90 days (31 vs. 40.1%, P = 0.028). The total number of BP excursions was associated with decreased odds of 24-h clinical recovery (OR = 0.88, 95% CI:0.80–0.96), 24-h neurological improvement (OR = 0.87, 95% CI: 0.81–0.94), 7-day functional improvement (common OR = 0.92, 95% CI: 0.87–0.97), 90-day functional improvement (common OR = 0.94, 95% CI: 0.88–0.98) and 90-day independent functional outcome (OR = 0.90, 95% CI: 0.82–0.98) in analyses adjusted for potential confounders. DBP excursions were independently associated with increased odds of any intracranial hemorrhage (OR = 1.26, 95% CI: 1.04–1.53). Conclusion: BP excursions above guideline thresholds during the first 24 h following tPA administration for AIS are common and are independently associated with adverse clinical outcomes.]]> Fri 11 Nov 2022 15:33:52 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:33397 Fri 01 Apr 2022 09:23:04 AEDT ]]>